Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 8/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5198047 | 0.87 | GRM5 (0.64) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL5199705 | 0.84 | GRM5 (0.70) | GRM5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2826482 | 0.84 | NPC1 (0.40) | GRM5NPC1RAB9ARIPK1SMN1; SMN2 | |
| SCHEMBL5200277 | 0.81 | PDE10A (0.56) | GRM5NPC1RAB9ARIPK1SMN1; SMN2 | |
| SCHEMBL5197589 | 0.78 | GRM5 (0.52) | GRM5NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL2829048 | 0.77 | GRM5 (0.46) | GRM5NPC1RAB9ARIPK1SMN1; SMN2 | |
| SCHEMBL5200154 | 0.77 | GRM5 (0.48) | GRM5NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL5200364 | 0.76 | GRM5 (0.46) | GRM5NPC1RAB9A | |
| SCHEMBL2830071 | 0.72 | GRM5 (0.39) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL5199425 | 0.71 | GRM5 (0.46) | GRM5NPC1RAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-A1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-10-17 | — | — | EP | claimed |
| WO-2006074884-A1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-07-20 | — | — | WO | claimed |
| EP-1844044-A1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006074884-A1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-07-20 | — | — | WO | disclosed |