Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.40 |
| ▸ | GCK | P35557 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5197589 | 0.90 | GRM5 (0.52) | GRM5NPC1RAB9AKCNH2KDM1A | |
| SCHEMBL2828971 | 0.86 | NPC1 (0.37) | GRM5NPC1RAB9AKCNH2KDM1A | |
| SCHEMBL5200154 | 0.81 | GRM5 (0.48) | GRM5NPC1RAB9AGCK | |
| SCHEMBL2827226 | 0.80 | GRM5 (0.41) | GRM5NPC1RAB9AKDM1AMAOB | |
| SCHEMBL5199705 | 0.79 | GRM5 (0.70) | GRM5NPC1RAB9A | |
| SCHEMBL5198047 | 0.78 | GRM5 (0.64) | GRM5NPC1RAB9A | |
| SCHEMBL2829284 | 0.76 | NPC1 (0.41) | GRM5NPC1RAB9AKCNH2KDM1A | |
| SCHEMBL5197860 | 0.76 | GRM5 (0.49) | GRM5NPC1RAB9A | |
| SCHEMBL5199075 | 0.73 | GRM5 (0.47) | GRM5NPC1RAB9A | |
| SCHEMBL5199425 | 0.71 | GRM5 (0.46) | GRM5NPC1RAB9AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-A1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006074884-A1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-07-20 | — | — | WO | disclosed |