Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAO1 | P09471 | 6/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 5/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.48 |
| ▸ | DRD4 | P21917 | 3/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26374152 | 0.94 | GNAO1 (0.57) | GNAO1CYP1A2HRH3DRD2CHRM1 | |
| SCHEMBL31273549 | 0.93 | GNAO1 (0.51) | GNAO1CYP1A2HRH3DRD2CHRM1 | |
| SCHEMBL31273564 | 0.93 | GNAO1 (0.51) | GNAO1CYP1A2HRH3DRD2CHRM1 | |
| Acetic Acid SCHEMBL29251905 | 0.89 | CHRM1 (0.51) | GNAO1CYP1A2HRH3DRD2CHRM1 | |
| SCHEMBL19033278 | 0.88 | GNAO1 (0.50) | GNAO1CYP1A2HRH3DRD2CHRM1 | |
| SCHEMBL29252643 | 0.88 | CHRM1 (0.47) | GNAO1CYP1A2HRH3DRD2CHRM1 | |
| SCHEMBL17424060 | 0.87 | GNAO1 (0.59) | GNAO1CYP1A2HRH3DRD2CHRM1 | |
| SCHEMBL7741719 | 0.86 | GNAO1 (0.49) | GNAO1HRH3DRD2CHRM1CHRM2 | |
| SCHEMBL23842232 | 0.86 | GNAO1 (0.46) | GNAO1CYP1A2HRH3DRD2CHRM1 | |
| SCHEMBL14371513 | 0.86 | CYP1A2 (0.57) | GNAO1CYP1A2HRH3DRD2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081759-A1 | BIFUNCTIONAL PI3K-ALPHA INHIBITORS AND USES THEREOF | RELAY THERAPEUTICS, INC. (US) | 2023-05-11 | — | — | WO | disclosed |
| US-20090105212-A1 | NOVEL ADENINE COMPOUND | Dainippon Sumitomo Pharma Co., Ltd. a corporation of Japan (JP) | 2009-04-23 | — | — | US | disclosed |
| EP-1828176-A1 | TETRAHYDROQUINOLINE ANALOGUES AS MUSCARINIC AGONISTS | Acadia Pharmaceuticals Inc. (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006068904-A1 | TETRAHYDROQUINOLINE ANALOGUES AS MUSCARINIC AGONISTS | ACADIA PHARMACEUTICALS INC. (US) | 2006-06-29 | — | — | WO | disclosed |
| EP-1613321-A2 | MUSCARINIC M1 RECEPTOR AGONISTS FOR PAIN MANAGEMENT | Acadia Pharmaceuticals Inc. (US) | 2006-01-11 | — | — | EP | disclosed |
| US-20050130961-A1 | Muscarinic M1 receptor agonists for pain management | ACADIA PHARMACEUTICALS INC. | 2005-06-16 | — | — | US | disclosed |
| WO-2004087158-A2 | MUSCARINIC M1 RECEPTOR AGONISTS FOR PAIN MANAGEMENT | ACADIA PHARMACEUTICALS INC. (US) | 2004-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050130961-A1 | Muscarinic M1 receptor agonists for pain management | CHRM1, CHRM3, CHRM2 | GNAO1 318/4885CYP1A2 1156/4885HRH3 272/4885 |
| US-20090105212-A1 | NOVEL ADENINE COMPOUND | XDH, ADORA1, NUDT1 | GNAO1 239/4885CYP1A2 164/4885HRH3 162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.