SCHEMBL5197889

SCHEMBL5197889

O=C(O)N1CCC(N[C@H](Cc2ccc(Cl)cc2)C(=O)N2CCC(N(CCn3ccnc3)C3CCCCC3)CC2)CC1

nearest known ligand 0.38

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MC4R P32245 12/20 0.38
ADAMTS5 Q9UNA0 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5459398 0.92 MC4R (0.40) MC4R
Hydrochloric Acid SCHEMBL5447607 0.91 MC4R (0.40) MC4RADAMTS5
SCHEMBL5449611 0.89 GPR119 (0.42) MC4R
SCHEMBL5370825 0.83 MC4R (0.40) MC4R
SCHEMBL5197541 0.81 EGLN3 (0.41)
SCHEMBL5197965 0.79 MC4R (0.44) MC4R
SCHEMBL5197473 0.78 MC4R (0.42) MC4R
SCHEMBL5450753 0.76 MC4R (0.44) MC4R
SCHEMBL5195017 0.75 CYP51A1 (0.45)
SCHEMBL5444005 0.74 MC4R (0.42) MC4R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1786809-A2 AMINOPIPERIDINE DERIVATIVES, PREPARATION THEREOF AND USE THEREOF AS MELANOCORTIN RECEPTOR AGONISTS Sanofi-Aventis (FR) 2007-05-23 EP disclosed
WO-2006021656-A2 AMINOPIPERIDINE DERIVATIVES, PREPARATION THEREOF AND USE THEREOF AS MELANOCORTIN RECEPTOR AGONISTS SANOFI-AVENTIS (FR) 2006-03-02 WO disclosed