Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5200538 | 1.00 | PPARG (0.42) | PPARGPPARAADRB2CHRM2CHRM1 | |
| SCHEMBL579976 | 0.87 | CHRM2 (0.46) | ADRB2CHRM2CHRM1MAPK1NPSR1 | |
| SCHEMBL580492 | 0.87 | CHRM2 (0.46) | ADRB2CHRM2CHRM1MAPK1NPSR1 | |
| SCHEMBL579637 | 0.87 | CHRM2 (0.46) | ADRB2CHRM2CHRM1MAPK1NPSR1 | |
| SCHEMBL5200483 | 0.84 | MAPK1 (0.49) | PPARGPPARAMAPK1NPSR1KMT2A | |
| SCHEMBL5198095 | 0.84 | MAPK1 (0.49) | PPARGPPARAMAPK1NPSR1KMT2A | |
| SCHEMBL615095 | 0.79 | MAPT (0.46) | ADRB2CHRM2CHRM1SIGMAR1KMT2A | |
| SCHEMBL5200533 | 0.79 | SIGMAR1 (0.46) | SIGMAR1HTR1A | |
| SCHEMBL11387106 | 0.78 | MEN1 (0.50) | NPSR1KMT2A | |
| SCHEMBL9231158 | 0.78 | LMNA (0.50) | NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633695-A4 | SMOOTH MUSCLE SPASMOLYTIC AGENTS | BRIDGE PHARMA INC (US) | 2007-12-12 | — | — | EP | disclosed |
| EP-1633695-A2 | SMOOTH MUSCLE SPASMOLYTIC AGENTS | Bridge Pharma, Inc. (US) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004105692-A2 | SMOOTH MUSCLE SPASMOLYTIC AGENTS | BRIDGE PHARMA, INC. (US) | 2004-12-09 | — | — | WO | disclosed |