Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5560879 | 0.86 | CYP1A2 (0.46) | KDM4EPOLBSMN1; SMN2CYP1A2KMT2A | |
| SCHEMBL26926832 | 0.83 | MAPK1 (0.49) | MAPK1CYP2C19TSHRNPC1ALDH1A1 | |
| SCHEMBL26927066 | 0.81 | MAPK1 (0.51) | MAPK1CYP2C19TSHRNPC1ALDH1A1 | |
| SCHEMBL5556813 | 0.79 | KMT2A (0.44) | CYP2C19ALDH1A1KDM4EPOLBCYP1A2 | |
| SCHEMBL360689 | 0.78 | NR1H2 (0.43) | KDM4EPOLBCYP1A2KMT2AGAA | |
| SCHEMBL20388555 | 0.78 | CYP1A2 (0.40) | ALDH1A1KDM4EPOLBCYP1A2KMT2A | |
| SCHEMBL537688 | 0.78 | CYP1A2 (0.47) | CYP2C19NPC1KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL13373558 | 0.77 | SMN1; SMN2 (0.58) | MAPK1TSHRALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL16796412 | 0.77 | KMT2A (0.42) | ALDH1A1KDM4EPOLBHSD17B10CYP1A2 | |
| SCHEMBL5196927 | 0.77 | CYP2C19 (0.41) | MAPK1CYP2C19TSHRNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814861-A1 | SUBSTITUTED 5-OXO PYRAZOLES AND [1,2,4]TRIAZOLES AS ANTIVIRAL AGENTS | SCHERING CORPORATION (US) | 2007-08-08 | — | — | EP | disclosed |
| US-7115749-B2 | Substituted 5-oxo pyrazoles and [1,2,4]triazoles as antiviral agents | SCHERING CORPORATION (US) | 2006-10-03 | — | — | US | disclosed |
| US-20060111412-A1 | For inhibiting hepatitis c virus RNA-dependent polymerase | SCHERING CORPORATION | 2006-05-25 | — | — | US | disclosed |
| WO-2006050035-A1 | SUBSTITUTED 5-OXO PYRAZOLES AND [1,2,4]TRIAZOLES AS ANTIVIRAL AGENTS | SCHERING CORPORATION (US) | 2006-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060111412-A1 | For inhibiting hepatitis c virus RNA-dependent polymerase | RNASE1, POLRMT, POLR2E | MAPK1 2071/4885CYP2C19 2077/4885TSHR 3149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.