L-740093

L-740093

SCHEMBL5198570

Cc1cccc(NC(=O)NC2N=C(N3CC4CCC(CC4)C3)c3ccccc3N(C)C2=O)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CCKBR P32239 20/20 1.00
KCNH2 Q12809 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
L-740093 SCHEMBL7627122 1.00 CCKBR (1.00) CCKBRKCNH2
L-740093 SCHEMBL31616330 1.00 CCKBR (1.00) CCKBRKCNH2
L-740093 SCHEMBL7818686 0.99 CCKBR (1.00) CCKBRKCNH2
SCHEMBL7819818 0.96 CCKBR (0.93) CCKBRKCNH2
SCHEMBL7816104 0.96 CCKBR (0.93) CCKBRKCNH2
Hydrochloric Acid SCHEMBL7818978 0.96 CCKBR (0.93) CCKBRKCNH2
SCHEMBL7824899 0.92 CCKBR (0.84) CCKBR
SCHEMBL7816801 0.91 CCKBR (0.84) CCKBRKCNH2
SCHEMBL7819955 0.91 CCKBR (0.84) CCKBRKCNH2
SCHEMBL7816805 0.91 CCKBR (0.84) CCKBRKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030191114-A1 Assay for and uses of peptide hormone receptor agonists KOPIN ALAN S (US) 2003-10-09 US claimed
EP-0652871-B1 BENZODIAZEPINE DERIVATIVES MERCK SHARP & DOHME (GB) 2001-10-17 EP claimed
EP-0869975-A4 ASSAY FOR AND USES OF PEPTIDE HORMONE RECEPTOR LIGANDS NEW ENGLAND MEDICAL CENTER INC (US) 1998-12-02 EP claimed
EP-0869975-A1 ASSAY FOR AND USES OF PEPTIDE HORMONE RECEPTOR LIGANDS NEW ENGLAND MEDICAL CENTER HOSPITALS, INC. (US) 1998-10-14 EP claimed
WO-1997021731-A1 ASSAY FOR AND USES OF PEPTIDE HORMONE RECEPTOR LIGANDS NEW ENGLAND MEDICAL CENTER HOSPITALS, INC. (US) 1997-06-19 WO claimed
US-5618812-A GASTRIN ANTAGONISTS; GASTROINTESTINAL DISORDERS MERCK SHARP & DOHME, LTD. (GB) 1997-04-08 US claimed
EP-0869975-B1 ASSAY FOR AND USES OF PEPTIDE HORMONE RECEPTOR LIGANDS NEW ENGLAND MEDICAL CENTER INC (US) 2007-08-15 EP disclosed
US-20030191114-A1 Assay for and uses of peptide hormone receptor agonists KOPIN ALAN S (US) 2003-10-09 US disclosed
US-6566080-B1 Detection of modulator of hormone receptor activity; obtain receptor sample, incubate with modulator, monitor adjustments in binding activity of receptor, adjustment in activity compared to control indicates modulator NEW ENGLAND MEDICAL CENTER 2003-05-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030191114-A1 Assay for and uses of peptide hormone receptor agonists SCTR, TRHR, GHRHR CCKBR 80/4885KCNH2 2784/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.