Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PRKCI | P41743 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9806449 | 0.81 | SELL (0.37) | HSD17B10 | |
| SCHEMBL5200338 | 0.76 | TYR (0.49) | MEN1CYP1A2MAPTTSHRKMT2A | |
| SCHEMBL5199656 | 0.76 | MEP1B (0.35) | ERN1MEN1CYP1A2MAPTTSHR | |
| SCHEMBL1829471 | 0.76 | ERN1 (0.34) | ERN1MEN1CYP1A2MAPTTSHR | |
| SCHEMBL5198649 | 0.76 | CYP3A4 (0.37) | ERN1MEN1CYP1A2MAPTTSHR | |
| SCHEMBL1831694 | 0.74 | GABRA1 (0.33) | — | |
| SCHEMBL5200570 | 0.73 | MEN1 (0.40) | MEN1CYP1A2MAPTTSHRKMT2A | |
| SCHEMBL1829639 | 0.73 | TP53 (0.37) | ERN1MEN1CYP1A2MAPTTSHR | |
| SCHEMBL12478909 | 0.72 | ERN1 (0.47) | ERN1 | |
| SCHEMBL12479023 | 0.72 | ERN1 (0.52) | ERN1MEN1MAPTKMT2APRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817300-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2007-08-15 | — | — | EP | disclosed |
| EP-1817301-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2007-08-15 | — | — | EP | disclosed |
| EP-1817296-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006057860-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2006-06-01 | — | — | WO | disclosed |
| WO-2006057869-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2006-06-01 | — | — | WO | disclosed |
| WO-2006057870-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2006-06-01 | — | — | WO | disclosed |