Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 4/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17377707 | 0.87 | GABRA1 (0.43) | MEN1MAPTKMT2ACYP1A2TSHR | |
| SCHEMBL5198498 | 0.86 | MEN1 (0.50) | MEN1MAPTKMT2ACYP1A2TSHR | |
| SCHEMBL3191260 | 0.84 | GABRA1 (0.52) | ESR1ESR2GABRA1GABRB2BACE1 | |
| SCHEMBL29429347 | 0.84 | GABRA1 (0.52) | ESR1ESR2GABRA1GABRB2BACE1 | |
| SCHEMBL9806449 | 0.78 | SELL (0.37) | HSD17B10ESR1ESR2ALDH1A1KDM4E | |
| SCHEMBL13264060 | 0.78 | ESR1 (0.36) | HSD17B10ESR1ESR2GABRA1GABRB2 | |
| SCHEMBL5200338 | 0.77 | TYR (0.49) | MEN1MAPTKMT2ACYP1A2TSHR | |
| SCHEMBL11116300 | 0.76 | MEN1 (0.40) | MEN1MAPTKMT2ACYP1A2TSHR | |
| SCHEMBL28551606 | 0.75 | PRKCI (0.55) | MEN1MAPTKMT2ATSHRESR1 | |
| SCHEMBL4965632 | 0.74 | TRPA1 (0.53) | MEN1MAPTKMT2AHSD17B10ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817300-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006057860-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2006-06-01 | — | — | WO | disclosed |