Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | PRKCG | P05129 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | LYN | P07948 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL883796 | 0.77 | EED (0.37) | TAAR1ALDH1A1MAPK1CHEK1HSD17B10 | |
| SCHEMBL31494286 | 0.76 | NPSR1 (0.53) | ALDH1A1MEN1KMT2AMAPTAR | |
| SCHEMBL7659797 | 0.76 | NPSR1 (0.53) | ALDH1A1MEN1KMT2AMAPTAR | |
| SCHEMBL16624995 | 0.74 | AURKA (0.64) | TAAR1ALDH1A1MAPTMAPK1CHEK1 | |
| SCHEMBL11317380 | 0.74 | MEN1 (0.55) | TAAR1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL16415443 | 0.74 | SCN9A (0.36) | ALDH1A1MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL31004502 | 0.74 | SCN9A (0.36) | ALDH1A1MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL29066282 | 0.73 | ACVRL1 (0.61) | ALDH1A1MEN1KMT2AMAPTAR | |
| SCHEMBL25124747 | 0.73 | ADRA2A (0.36) | ALDH1A1KMT2AMAPTHTTHSD17B10 | |
| SCHEMBL19476585 | 0.73 | FLT4 (0.57) | ALDH1A1MEN1KMT2AMAPTAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802603-A1 | QUINOLINE DERIVATIVES | AstraZeneca AB (SE) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006040522-A1 | QUINOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2006-04-20 | — | — | WO | disclosed |