Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.44 |
| ▸ | GLS | O94925 | 2/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12844313 | 0.84 | RIPK1 (0.43) | RIPK1SLC6A7GLSTRPV1DPP4 | |
| SCHEMBL3715603 | 0.81 | RIPK1 (0.48) | RIPK1SLC6A7GLSPDE4DTRPV1 | |
| SCHEMBL25059133 | 0.81 | TRPV1 (0.43) | PDE10ARIPK1SLC6A7GLSTRPV1 | |
| SCHEMBL8326977 | 0.79 | PLD1 (0.57) | PDE10AHIF1A | |
| SCHEMBL14094520 | 0.78 | NPC1 (0.52) | RIPK1SLC6A7TRPV1 | |
| SCHEMBL2000100 | 0.78 | HTR3E (0.54) | RIPK1SLC6A7GLSTRPV1DPP4 | |
| SCHEMBL5802698 | 0.76 | LMNA (0.60) | RIPK1SLC6A7GLSPDE4DTRPV1 | |
| SCHEMBL9195108 | 0.75 | PDE10A (0.44) | PDE10APDE4DPDE2APDE1B | |
| SCHEMBL31294135 | 0.75 | DPP4 (0.45) | PDE10ARIPK1SLC6A7GLSDPP4 | |
| SCHEMBL24928457 | 0.75 | DPP4 (0.45) | PDE10ARIPK1SLC6A7GLSDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799668-A1 | HETEROCYCLIC DERIVATIVES AND THEIR USE AS MEDIATORS OF STEAROYL-COA DESATURASE | XENON PHARMACEUTICALS INC. (CA) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006034338-A1 | HETEROCYCLIC DERIVATIVES AND THEIR USE AS MEDIATORS OF STEAROYL-COA DESATURASE | XENON PHARMACEUTICALS INC. (CA) | 2006-03-30 | — | — | WO | disclosed |