Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 4/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.54 |
| ▸ | RAD52 | P43351 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MAPKAPK2 | P49137 | 6/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5199413 | 0.85 | CD274 (0.46) | ADRA2AADRA2CADRA2BGFERTDP1 | |
| SCHEMBL5200210 | 0.85 | PLK4 (0.53) | KDM1ASLC2A1JAK2 | |
| SCHEMBL5200215 | 0.80 | JAK2 (0.54) | JAK2EGFRJAK3CDK2TNIK | |
| SCHEMBL30854951 | 0.80 | NCF1 (0.50) | KDM1ATDP1JAK2JAK3HTR6 | |
| SCHEMBL4078840 | 0.76 | EGFR (0.60) | ADRA2AADRA2CADRA2BKDM1AGLA | |
| SCHEMBL30925347 | 0.74 | ADRA2C (0.50) | ADRA2AADRA2CADRA2BRAD52GFER | |
| SCHEMBL27020409 | 0.73 | EGFR (0.64) | ADRA2AADRA2CTDP1JAK2EGFR | |
| SCHEMBL30306480 | 0.72 | EGFR (0.60) | ADRA2AADRA2CADRA2BJAK2EGFR | |
| SCHEMBL12325149 | 0.72 | BRD4 (0.64) | RAD52GFERJAK2EGFRJAK3 | |
| SCHEMBL6968717 | 0.72 | BRD4 (0.61) | ADRA2AADRA2CADRA2BRAD52GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551813-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2007-07-11 | — | — | EP | disclosed |
| EP-1551813-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004032882-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-04-22 | — | — | WO | disclosed |