Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.54 |
| ▸ | JAK3 | P52333 | 2/20 | 0.54 |
| ▸ | TNK2 | Q07912 | 4/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5199072 | 0.80 | ADRA2A (0.54) | JAK2JAK3TNIKEGFRCDK2 | |
| SCHEMBL13485384 | 0.74 | JAK2 (0.80) | JAK2JAK3TNK2FLT3AXL | |
| SCHEMBL29531326 | 0.73 | AXL (0.60) | JAK2JAK3TNK2KITPDGFRA | |
| SCHEMBL24773731 | 0.73 | JAK2 (0.48) | JAK2JAK3TNK2KITPDGFRA | |
| SCHEMBL5475439 | 0.70 | VCP (0.60) | JAK2JAK3KDRBRD4CCNA2 | |
| SCHEMBL2061550 | 0.70 | TNK2 (0.57) | JAK2JAK3TNK2PDGFRAKDR | |
| SCHEMBL29578146 | 0.70 | HTR1D (0.51) | JAK2JAK3KITPDGFRAKDR | |
| SCHEMBL29530850 | 0.69 | AXL (0.55) | JAK2JAK3TNK2KITPDGFRA | |
| SCHEMBL14504076 | 0.69 | JAK3 (0.45) | JAK2JAK3TNK2KITPDGFRA | |
| SCHEMBL3955783 | 0.68 | AXL (0.59) | JAK2JAK3TNK2KITPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551813-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2007-07-11 | — | — | EP | claimed |
| EP-1551813-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-07-13 | — | — | EP | claimed |
| WO-2004032882-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-04-22 | — | — | WO | claimed |