Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | SLC6A15 | Q9H2J7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5199608 | 0.90 | GPR119 (0.49) | CHRM2CHRM1GPR119KDM4EALDH1A1 | |
| SCHEMBL4894455 | 0.85 | GPR119 (0.53) | GPR119 | |
| SCHEMBL5223968 | 0.85 | CHRM2 (0.49) | CHRM2CHRM1GPR119KDM4EALDH1A1 | |
| SCHEMBL27684448 | 0.84 | HTR6 (0.40) | CHRM2CHRM1GPR119KDM4EHTR6 | |
| SCHEMBL13989715 | 0.81 | HTR6 (0.45) | CHRM2CHRM1HTR6LMNAHTT | |
| Hydrochloric Acid SCHEMBL4901628 | 0.80 | HTR6 (0.44) | CHRM2CHRM1HTR6LMNAHTT | |
| SCHEMBL5228645 | 0.77 | CHRM2 (0.48) | CHRM2CHRM1GPR119SMN1; SMN2LMNA | |
| SCHEMBL5198989 | 0.76 | CHRM2 (0.46) | CHRM2CHRM1GPR119SMN1; SMN2LMNA | |
| SCHEMBL4892781 | 0.76 | HTR2C (0.47) | HTR6CYP3A4 | |
| SCHEMBL5198338 | 0.76 | CHRM2 (0.51) | CHRM2CHRM1GPR119SMN1; SMN2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814873-A2 | 5-SULFONYL-1-PIPERIDINYL SUBSTITUTED INDOLE DERIVATIVES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006038006-A2 | 5-SULFONYL-1-PIPERIDINYL SUBSTITUTED INDOLE DERIVATIVES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2006-04-13 | — | — | WO | disclosed |