Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5199217 | 0.90 | CHRM2 (0.45) | GPR119CHRM2CHRM1HTR6KDM4E | |
| SCHEMBL5223968 | 0.85 | CHRM2 (0.49) | GPR119CHRM2CHRM1KDM4EALDH1A1 | |
| SCHEMBL4892121 | 0.85 | GPR119 (0.53) | GPR119 | |
| SCHEMBL27703343 | 0.84 | HTR6 (0.42) | GPR119HTR6LMNA | |
| SCHEMBL5310120 | 0.81 | GPR119 (0.44) | GPR119CHRM2CHRM1ALDH1A1PTGDR2 | |
| SCHEMBL5199029 | 0.81 | NPSR1 (0.42) | GPR119CHRM2CHRM1KDM4EALDH1A1 | |
| SCHEMBL5228645 | 0.80 | CHRM2 (0.48) | GPR119CHRM2CHRM1LMNAHTT | |
| SCHEMBL5198989 | 0.80 | CHRM2 (0.46) | GPR119CHRM2CHRM1LMNAHTT | |
| SCHEMBL5196493 | 0.79 | GPR119 (0.45) | GPR119CHRM2CHRM1ALDH1A1LMNA | |
| SCHEMBL4898957 | 0.76 | HTR2C (0.45) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814873-A2 | 5-SULFONYL-1-PIPERIDINYL SUBSTITUTED INDOLE DERIVATIVES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006038006-A2 | 5-SULFONYL-1-PIPERIDINYL SUBSTITUTED INDOLE DERIVATIVES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2006-04-13 | — | — | WO | disclosed |