Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 20/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5197857 | 0.85 | TGFBR1 (0.42) | TGFBR1MAPK14KDRRIPK2 | |
| SCHEMBL5199929 | 0.82 | TGFBR1 (0.60) | TGFBR1MAPK14KDRTHRB | |
| SCHEMBL5199684 | 0.81 | TGFBR1 (0.37) | TGFBR1MAPK14KDRRIPK2THRB | |
| SCHEMBL5199767 | 0.80 | TGFBR1 (0.44) | TGFBR1MAPK14KDRRIPK2THRB | |
| SCHEMBL5198937 | 0.77 | TGFBR1 (0.37) | TGFBR1MAPK14KDRRIPK2 | |
| SCHEMBL38654004 | 0.74 | CCR1 (0.39) | TGFBR1MAPK14KDRRIPK2THRB | |
| SCHEMBL5930884 | 0.73 | TGFBR1 (0.39) | TGFBR1MAPK14RIPK2 | |
| SCHEMBL5198215 | 0.73 | TGFBR1 (0.44) | TGFBR1MAPK14 | |
| SCHEMBL38654653 | 0.72 | CCR1 (0.37) | TGFBR1MAPK14KDRTHRB | |
| SCHEMBL5198226 | 0.71 | TGFBR1 (0.46) | TGFBR1MAPK14THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070275968-A1 | Substituted Biphenyl Derivative | SANKYO COMPANY, LIMITED (JP) | 2007-11-29 | — | — | US | disclosed |
| EP-1798229-A1 | SUBSTITUTED BIPHENYL DERIVATIVE | Sankyo Company, Limited (JP) | 2007-06-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275968-A1 | Substituted Biphenyl Derivative | COL2A1, COL1A1, FGFR3 | TGFBR1 40/4885MAPK14 2998/4885KDR 1163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.