SCHEMBL5199852

SCHEMBL5199852

CCCCOC(=O)NC(CC(=O)O)c1ccc(OC)c(OC)c1OC

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.40
ALDH1A1 P00352 1/20 0.40
LMNA P02545 1/20 0.40
TSHR P16473 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
CTSA P10619 7/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
FAAH O00519 1/20 0.38
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
CASP1 P29466 1/20 0.38
KDM4E B2RXH2 1/20 0.38
HSD17B10 Q99714 1/20 0.38
HPGD P15428 1/20 0.38
CNR2 P34972 1/20 0.37
MEN1 O00255 1/20 0.37
GAA P10253 1/20 0.37
MAPT P10636 1/20 0.37
HTT P42858 1/20 0.37
KMT2A Q03164 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5088792 0.85 CTSA (0.51) ALDH1A1CTSASMN1; SMN2KDM4EHSD17B10
SCHEMBL5198522 0.81 POLB (0.45) L3MBTL1ALDH1A1LMNATSHRNPSR1
SCHEMBL5499794 0.81 POLB (0.57) L3MBTL1ALDH1A1LMNASMN1; SMN2FAAH
SCHEMBL2149058 0.80 FAAH (0.43) L3MBTL1ALDH1A1LMNATSHRNPSR1
SCHEMBL2320404 0.77 FAAH (0.59) L3MBTL1ALDH1A1LMNANPSR1CTSA
SCHEMBL5089567 0.76 CTSA (0.54) CTSA
SCHEMBL844472 0.75 SMN1; SMN2 (0.57) L3MBTL1ALDH1A1LMNATSHRSMN1; SMN2
SCHEMBL14040614 0.75 SMN1; SMN2 (0.57) L3MBTL1ALDH1A1LMNATSHRSMN1; SMN2
SCHEMBL5503390 0.75 CTSA (0.47) CTSAFAAH
SCHEMBL3870707 0.75 CYP26A1 (0.50) L3MBTL1LMNATSHRCTSASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1576179-A4 METHODS AND COMPOSITIONS FOR INDUCING APOPTOSIS IN CANCER CELLS IRM LLC (BM) 2007-06-06 EP disclosed
EP-1576179-A2 METHODS AND COMPOSITIONS FOR INDUCING APOPTOSIS IN CANCER CELLS IRM LLC (BM) 2005-09-21 EP disclosed
WO-2004050895-A2 METHODS AND COMPOSITIONS FOR INDUCING APOPTOSIS IN CANCER CELLS IRM LLC (BM) 2004-06-17 WO disclosed
EP-1399468-A1 2-((N-(2-AMINO-3-(HETEROARYL OR ARYL)PROPIONYL)-AMINOACYL)-AMINO)-ALKYLBORONIC ACID DERIVATIVES Novartis AG (CH) 2004-03-24 EP disclosed
WO-2002096933-A1 2-{[N-(2-AMINO-3-(HETEROARYL OR ARYL)PROPIONYL)-AMINOACYL]-AMINO}-ALKYLBORONIC ACID DERIVATIVES NOVARTIS AG (CH) 2002-12-05 WO disclosed