Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 8/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | MDM4 | O15151 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27561654 | 1.00 | PTPN1 (0.44) | PTPN1CTSLCTSBCTSSCTSK | |
| SCHEMBL5205166 | 0.88 | CASP3 (0.48) | CTSLCTSBCTSSCTSKMDM4 | |
| SCHEMBL27571135 | 0.88 | CASP3 (0.48) | CTSLCTSBCTSSCTSKMDM4 | |
| SCHEMBL5201715 | 0.86 | CASP3 (0.44) | CTSLCTSBCTSSCTSKCASP3 | |
| SCHEMBL5201718 | 0.86 | CASP3 (0.44) | CTSLCTSBCTSSCTSKCASP3 | |
| SCHEMBL27561296 | 0.86 | CASP3 (0.44) | CTSLCTSBCTSSCTSKCASP3 | |
| SCHEMBL8008213 | 0.81 | TNF (0.43) | PTPN1MDM4TP53CASP3 | |
| SCHEMBL4631066 | 0.81 | PSEN1 (0.54) | CTSLCTSBCTSSCTSK | |
| SCHEMBL5532444 | 0.81 | PSEN1 (0.54) | CTSLCTSBCTSSCTSK | |
| SCHEMBL3492066 | 0.81 | PSEN1 (0.54) | CTSLCTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1400521-B1 | PIPERAZINE COMPOUNDS | KOWA CO (JP) | 2007-11-07 | — | — | EP | disclosed |
| EP-1400521-A1 | PIPERAZINE COMPOUNDS | Kowa Co., Ltd. (JP) | 2004-03-24 | — | — | EP | disclosed |
| US-6432957-B1 | ANTIASTHMA; ANTIALLERGENS; RHEUMATIC DISEASES; ANTIINFLAMMATORY AGENTS | KOWA CO., LTD. (JP) | 2002-08-13 | — | — | US | disclosed |