Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 4/20 | 0.44 |
| ▸ | CTSL | P07711 | 2/20 | 0.44 |
| ▸ | CTSB | P07858 | 2/20 | 0.44 |
| ▸ | CTSS | P25774 | 2/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27561296 | 1.00 | CASP3 (0.44) | CASP3CTSLCTSBCTSSCTSK | |
| SCHEMBL5201718 | 1.00 | CASP3 (0.44) | CASP3CTSLCTSBCTSSCTSK | |
| SCHEMBL5205166 | 0.94 | CASP3 (0.48) | CASP3CTSLCTSBCTSSCTSK | |
| SCHEMBL27571135 | 0.94 | CASP3 (0.48) | CASP3CTSLCTSBCTSSCTSK | |
| SCHEMBL30449394 | 0.87 | CASP3 (0.46) | CASP3CTSLCTSBCTSSCTSK | |
| SCHEMBL5200510 | 0.86 | PTPN1 (0.44) | CASP3CTSLCTSBCTSSCTSK | |
| SCHEMBL27561654 | 0.86 | PTPN1 (0.44) | CASP3CTSLCTSBCTSSCTSK | |
| SCHEMBL5201071 | 0.84 | CASP3 (0.53) | CASP3CTSLCTSBCTSSCTSK | |
| SCHEMBL24579472 | 0.80 | CASP3 (0.49) | CASP3CTSLCTSBCTSSCTSK | |
| SCHEMBL29697620 | 0.80 | CASP3 (0.49) | CASP3CTSLCTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1400521-B1 | PIPERAZINE COMPOUNDS | KOWA CO (JP) | 2007-11-07 | — | — | EP | disclosed |
| EP-1400521-A1 | PIPERAZINE COMPOUNDS | Kowa Co., Ltd. (JP) | 2004-03-24 | — | — | EP | disclosed |
| US-6432957-B1 | ANTIASTHMA; ANTIALLERGENS; RHEUMATIC DISEASES; ANTIINFLAMMATORY AGENTS | KOWA CO., LTD. (JP) | 2002-08-13 | — | — | US | disclosed |