Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 4/20 | 0.56 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 5/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5201578 | 0.99 | HTR1B (0.54) | HTR1BTAAR1ADRA1AADRA2CADRA1D | |
| SCHEMBL4992561 | 0.84 | LMNA (0.58) | HTR1BTAAR1ADRA1AADRA2CADRA1D | |
| SCHEMBL5204185 | 0.82 | HTR1D (0.49) | HTR1BTAAR1ADRA1AADRA2CADRA1D | |
| SCHEMBL5200574 | 0.81 | HTR1D (0.49) | HTR1BTAAR1ADRA1AADRA2CADRA1D | |
| Hydrochloric Acid SCHEMBL5205837 | 0.81 | HTR1D (0.48) | HTR1BTAAR1ADRA1AADRA2CADRA1D | |
| Hydrochloric Acid SCHEMBL5202905 | 0.80 | HTR1D (0.48) | HTR1BTAAR1ADRA1AADRA2CADRA1D | |
| SCHEMBL5201601 | 0.79 | NISCH (0.56) | HTR1BADRA1AADRA2CADRA1DADRA1B | |
| SCHEMBL5205731 | 0.79 | HTR1B (0.55) | HTR1BTAAR1ADRA1AADRA2CADRA1D | |
| SCHEMBL5200888 | 0.79 | RAD52 (0.49) | HTR1BTAAR1ADRA1AADRA2CADRA1D | |
| SCHEMBL4993472 | 0.79 | RAD52 (0.49) | HTR1BTAAR1ADRA1AADRA2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0887346-B1 | N-Phenyl-alkylsulfonamide derivatives, their preparation and their use as alpha1A/1L adrenoceptor agonists | HOFFMANN LA ROCHE (CH) | 2007-12-12 | — | — | EP | disclosed |
| EP-0887346-B1 | N-Phenyl-alkylsulfonamide derivatives, their preparation and their use as alpha1A/1L adrenoceptor agonists | HOFFMANN LA ROCHE (CH) | 2007-12-12 | — | — | EP | disclosed |