Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR2E3 | Q9Y5X4 | 17/20 | 0.59 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4481398 | 0.87 | MT-CO2 (0.50) | NR2E3MT-CO2RAB9ANPC1 | |
| SCHEMBL6120531 | 0.85 | NPC1 (0.60) | RAB9ANPC1 | |
| SCHEMBL6126326 | 0.85 | ACHE (0.58) | RAB9ANPC1 | |
| SCHEMBL1664926 | 0.82 | ACHE (0.54) | RAB9ANPC1 | |
| SCHEMBL5190803 | 0.81 | NR2E3 (0.65) | NR2E3RAB9ANPC1 | |
| SCHEMBL8769900 | 0.81 | ACHE (0.54) | RAB9ANPC1 | |
| SCHEMBL6126388 | 0.81 | ACHE (0.54) | RAB9ANPC1 | |
| SCHEMBL5205370 | 0.81 | ALDH1A1 (0.48) | — | |
| SCHEMBL1664044 | 0.80 | NPC1 (0.53) | NR2E3RAB9ANPC1 | |
| SCHEMBL17072263 | 0.80 | FGFR1 (0.59) | RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833829-A2 | BENZAMIDE SUBSTITUTED IMIDAZO- AND PYRROLO-PYRIDINES AS PROTEIN KINASE INHIBITORS | F. Hoffmann-Roche AG (CH) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006066913-A2 | BENZAMIDE SUBSTITUTED IMIDAZO- AND PYROLO-PYRIDINES AS PROTEIN KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-29 | — | — | WO | disclosed |