Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5264677 | 0.89 | MAPT (0.37) | MAPTTHRBHSPA9SMN1; SMN2ADRA2A | |
| Hydrochloric Acid SCHEMBL5201481 | 0.79 | NPSR1 (0.40) | MAPTHSPA9SMN1; SMN2ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL1514586 | 0.70 | LMNA (0.40) | MAPTSMN1; SMN2ALDH1A1KMT2AGAA | |
| Hydrochloric Acid SCHEMBL1514370 | 0.69 | RECQL (0.39) | MAPTSMN1; SMN2ALDH1A1KMT2AGAA | |
| SCHEMBL5204172 | 0.69 | NPSR1 (0.41) | MAPTHSPA9ALDH1A1KMT2ACYP1A2 | |
| Hydrochloric Acid SCHEMBL1514313 | 0.69 | LMNA (0.39) | MAPTSMN1; SMN2ALDH1A1KMT2AGAA | |
| SCHEMBL21162020 | 0.69 | MAPK1 (0.47) | MAPTSMN1; SMN2ALDH1A1KMT2AGAA | |
| SCHEMBL31572373 | 0.68 | NPSR1 (0.39) | MAPTTHRBSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL5169982 | 0.67 | CYP2C19 (0.44) | ALDH1A1GAAHTT | |
| SCHEMBL6606358 | 0.66 | ALDH1A1 (0.44) | MAPTTHRBADRA2APNMTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748999-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | AstraZeneca AB (SE) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005075461-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | WO | disclosed |