Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.37 |
| ▸ | MEN1 | O00255 | 6/20 | 0.37 |
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | HTT | P42858 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | NPY1R | P25929 | 1/20 | 0.34 |
| ▸ | NPY2R | P49146 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5200742 | 0.89 | MAPT (0.37) | MAPTKMT2AMEN1LMNAADRA2A | |
| SCHEMBL5204172 | 0.80 | NPSR1 (0.41) | MAPTKMT2AMEN1L3MBTL1ALDH1A1 | |
| SCHEMBL29993320 | 0.76 | HDAC3 (0.43) | ALDH1A1HTTPDE2A | |
| SCHEMBL16515363 | 0.72 | ALDH1A1 (0.39) | MAPTKMT2AMEN1ALDH1A1HTT | |
| SCHEMBL23647373 | 0.70 | HDAC4 (0.44) | — | |
| Hydrochloric Acid SCHEMBL1514370 | 0.70 | RECQL (0.39) | MAPTKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL5169163 | 0.70 | KMT2A (0.42) | MAPTKMT2ALMNAALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1514586 | 0.69 | LMNA (0.40) | MAPTKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL19813471 | 0.68 | PDE2A (0.36) | MAPTKMT2AMEN1L3MBTL1ALDH1A1 | |
| SCHEMBL20476242 | 0.68 | NPSR1 (0.47) | MAPTKMT2AMEN1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748999-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | AstraZeneca AB (SE) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005075461-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | WO | disclosed |