Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 4/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 13/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 10/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 10/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 7/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5201887 | 0.99 | ADRA1A (0.50) | NISCHADRA1AADRA1DADRA1BADRA2A | |
| SCHEMBL5206394 | 0.87 | ADRA1A (0.54) | NISCHADRA1AADRA1DADRA1BADRA2A | |
| SCHEMBL5201006 | 0.86 | ADRA1A (0.62) | NISCHADRA1AADRA1DADRA1BADRA2A | |
| Hydrochloric Acid SCHEMBL5201136 | 0.86 | ADRA1A (0.53) | NISCHADRA1AADRA1DADRA1BADRA2A | |
| SCHEMBL5201523 | 0.86 | NISCH (0.51) | NISCHADRA1AADRA1DADRA1BADRA2A | |
| Hydrochloric Acid SCHEMBL5204266 | 0.85 | ADRA1A (0.61) | NISCHADRA1AADRA1DADRA1BADRA2A | |
| Hydrochloric Acid SCHEMBL5206302 | 0.85 | ADRA1A (0.50) | NISCHADRA1AADRA1DADRA1BADRA2A | |
| SCHEMBL5203725 | 0.83 | ADRA1A (0.49) | NISCHADRA1AADRA1DADRA1BADRA2A | |
| SCHEMBL14340664 | 0.83 | ADRA1A (0.53) | NISCHADRA1AADRA1DADRA1BADRA2A | |
| SCHEMBL5203763 | 0.81 | ADRA1A (0.53) | NISCHADRA1AADRA1DADRA1BADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0887346-B1 | N-Phenyl-alkylsulfonamide derivatives, their preparation and their use as alpha1A/1L adrenoceptor agonists | HOFFMANN LA ROCHE (CH) | 2007-12-12 | — | — | EP | claimed |
| EP-0887346-A2 | Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives, their preparation and their use as alpha1A/1L adrenoceptor agonists | F. HOFFMANN-LA ROCHE AG (CH) | 1998-12-30 | — | — | EP | claimed |
| EP-0887346-B1 | N-Phenyl-alkylsulfonamide derivatives, their preparation and their use as alpha1A/1L adrenoceptor agonists | HOFFMANN LA ROCHE (CH) | 2007-12-12 | — | — | EP | disclosed |
| EP-0887346-A2 | Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives, their preparation and their use as alpha1A/1L adrenoceptor agonists | F. HOFFMANN-LA ROCHE AG (CH) | 1998-12-30 | — | — | EP | disclosed |