Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | TYR | P14679 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5200338 | 0.81 | TYR (0.49) | TSHRMEN1CYP1A2MAPTKMT2A | |
| SCHEMBL16335022 | 0.78 | ERN1 (0.35) | TSHRMEN1CYP1A2MAPTKMT2A | |
| SCHEMBL5200269 | 0.76 | MEN1 (0.48) | TSHRMEN1CYP1A2MAPTKMT2A | |
| SCHEMBL11199700 | 0.75 | IGF1R (0.40) | TSHRMEN1CYP1A2MAPTKMT2A | |
| SCHEMBL1801222 | 0.75 | CYP3A4 (0.48) | TSHRMAPTHSD17B10CYP3A4PIK3CA | |
| SCHEMBL3378789 | 0.75 | MMP2 (0.44) | TSHRMEN1MAPTKMT2AHSD17B10 | |
| SCHEMBL27550595 | 0.73 | CYP3A4 (0.50) | TSHRHSD17B10CYP3A4PIK3CAESR1 | |
| SCHEMBL5199170 | 0.73 | TDP1 (0.43) | TSHRKMT2ACYP3A4IMPDH2 | |
| SCHEMBL5240456 | 0.71 | TYR (0.38) | MEN1MAPTKMT2ATYRESR1 | |
| SCHEMBL4385600 | 0.71 | TDP1 (0.48) | TSHRHSD17B10CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817301-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006057870-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2006-06-01 | — | — | WO | disclosed |