Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 13/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5198328 | 0.89 | TGFBR1 (0.49) | TGFBR1MAPK14ALOX5CNR2JAK2 | |
| SCHEMBL5198595 | 0.88 | TGFBR1 (0.48) | TGFBR1MAPK14CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL5199257 | 0.86 | TGFBR1 (0.45) | TGFBR1MAPK14CNR1CNR2JAK1 | |
| SCHEMBL6251548 | 0.86 | TGFBR1 (0.62) | TGFBR1MAPK14ALOX5JAK2JAK1 | |
| SCHEMBL5198385 | 0.82 | TGFBR1 (0.43) | TGFBR1MAPK14CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL5197598 | 0.82 | TGFBR1 (0.57) | TGFBR1MAPK14CYP2D6CNR1 | |
| SCHEMBL5228813 | 0.82 | TGFBR1 (0.50) | TGFBR1CYP2C9CYP2C19JAK1 | |
| SCHEMBL5197802 | 0.80 | TGFBR1 (0.62) | TGFBR1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL5198925 | 0.80 | TGFBR1 (0.49) | TGFBR1MAPK14 | |
| SCHEMBL5199327 | 0.80 | TGFBR1 (0.48) | TGFBR1MAPK14CYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070275968-A1 | Substituted Biphenyl Derivative | SANKYO COMPANY, LIMITED (JP) | 2007-11-29 | — | — | US | disclosed |
| EP-1798229-A1 | SUBSTITUTED BIPHENYL DERIVATIVE | Sankyo Company, Limited (JP) | 2007-06-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275968-A1 | Substituted Biphenyl Derivative | COL2A1, COL1A1, FGFR3 | TGFBR1 40/4885MAPK14 2998/4885ALOX5 2942/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.