SCHEMBL5201077

SCHEMBL5201077

CC(C)(C)OC(=O)Nc1ccc2cc(OC(=O)O)sc2c1

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.42
CA1 P00915 1/20 0.42
CA9 Q16790 1/20 0.42
CA2 P00918 1/20 0.40
PSMB8 P28062 1/20 0.39
ACSS2 Q9NR19 1/20 0.39
HDAC1 Q13547 1/20 0.39
CYP17A1 P05093 2/20 0.38
KAT6A Q92794 1/20 0.38
ALDH1A1 P00352 1/20 0.38
GAA P10253 1/20 0.38
LEF1 Q9UJU2 1/20 0.37
ACHE P22303 1/20 0.37
BACE1 P56817 1/20 0.37
GLS O94925 1/20 0.37
NAMPT P43490 1/20 0.37
MAP4K4 O95819 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1090962 0.83 HDAC1 (0.48) CA12CA1CA9CA2PSMB8
SCHEMBL6230442 0.83 CA12 (0.47) CA12CA1CA9CA2PSMB8
SCHEMBL3968727 0.76 CA12 (0.48) CA12CA1CA9PSMB8ACSS2
SCHEMBL5383433 0.74 MEN1 (0.61) CA12CA1CA9PSMB8ACSS2
SCHEMBL4636496 0.73 LIPE (0.52) PSMB8CYP17A1ALDH1A1GAANAMPT
SCHEMBL28701306 0.73 HTR2C (0.50) CA12CA1CA9PSMB8HDAC1
SCHEMBL14079744 0.73 LDHA (0.67) ALDH1A1GAA
SCHEMBL14554346 0.73 TRPV1 (0.62) ALDH1A1
SCHEMBL2055274 0.73 LCK (0.52) GAAMAP4K4
SCHEMBL16396248 0.73 HDAC1 (0.48) CA12CA1CA9PSMB8ACSS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1527073-B1 BENZOTHIOPHENE UREA, BENZOFURANE UREA, AND INDOLE UREA, AND USE OF THE SAME AS ALPHA-7 ACHR AGONISTS BAYER HEALTHCARE AG (DE) 2007-08-22 EP disclosed
EP-1461335-B1 2-HETEROARYLCARBOXYLIC ACID AMIDES BAYER HEALTHCARE AG (DE) 2007-02-28 EP disclosed
EP-1527073-A1 BENZOTHIOPHENE UREA, BENZOFURANE UREA, AND INDOLE UREA, AND USE OF THE SAME AS ALPHA-7 ACHR AGONISTS Bayer HealthCare AG (DE) 2005-05-04 EP disclosed
EP-1461335-A1 2-HETEROARYLCARBOXYLIC ACID AMIDES Bayer HealthCare AG (DE) 2004-09-29 EP disclosed
WO-2004013136-A1 BENZOTHIOPHENE UREA, BENZOFURANE UREA, AND INDOLE UREA, AND USE OF THE SAME AS ALPHA-7 ACHR AGONISTS BAYER HEALTHCARE AG (DE) 2004-02-12 WO disclosed
WO-2003055878-A1 2-HETEROARYLCARBOXYLIC ACID AMIDES BAYER HEALTHCARE AG (DE) 2003-07-10 WO disclosed