Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL5201120 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2MAPTMCHR1TDP1ADRB1 | |
| SCHEMBL3552397 | 0.88 | MAPT (0.56) | SMN1; SMN2MAPTMCHR1TDP1NPBWR1 | |
| SCHEMBL9660476 | 0.88 | MAPT (0.56) | SMN1; SMN2MAPTMCHR1TDP1NPBWR1 | |
| SCHEMBL3552399 | 0.88 | MAPT (0.56) | SMN1; SMN2MAPTMCHR1TDP1NPBWR1 | |
| SCHEMBL5201129 | 0.84 | MAPT (0.41) | SMN1; SMN2MAPTMCHR1ADRB1SIRT6 | |
| Nitrobenzene SCHEMBL27746452 | 0.79 | LMNA (0.48) | MAPTTDP1DPP4SLC6A3ALDH1A1 | |
| 4-Nitroaniline SCHEMBL3413641 | 0.78 | ALDH1A1 (0.50) | SMN1; SMN2MAPTTDP1DPP4SLC6A3 | |
| SCHEMBL28149835 | 0.74 | MAPT (0.44) | SMN1; SMN2MAPTMCHR1TDP1NPBWR1 | |
| SCHEMBL3554528 | 0.73 | MAPT (0.48) | SMN1; SMN2MAPTMCHR1SIRT6NPBWR1 | |
| SCHEMBL3885054 | 0.73 | MAPT (0.61) | SMN1; SMN2MAPTMCHR1SLC6A3NPBWR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748999-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | AstraZeneca AB (SE) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005075461-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | WO | disclosed |