Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 4-Nitroaniline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 4-Nitroaniline SCHEMBL5768376 | 0.94 | ALDH1A1 (0.44) | ALDH1A1KMT2AMAPTMEN1PKM | |
| 4-Nitroaniline SCHEMBL28421782 | 0.93 | KDM1A (0.45) | ALDH1A1KMT2AMAPTMEN1PKM | |
| 4-Nitroaniline SCHEMBL6600220 | 0.92 | ALDH1A1 (0.42) | ALDH1A1KMT2AMAPTMEN1PKM | |
| 4-Nitroaniline SCHEMBL16269538 | 0.89 | SLC6A3 (0.40) | ALDH1A1KMT2AMAPTMEN1PKM | |
| Nitrobenzene SCHEMBL27746452 | 0.87 | LMNA (0.48) | ALDH1A1KMT2AMAPTMEN1SLC6A3 | |
| 4-Nitroaniline SCHEMBL3397241 | 0.87 | SLC6A3 (0.39) | ALDH1A1KMT2AMAPTMEN1PKM | |
| Phenylalanine SCHEMBL18957689 | 0.85 | ALPI (0.44) | KMT2AMEN1PKMDPP4EPHX1 | |
| Phenylalanine SCHEMBL8981660 | 0.82 | DPP4 (0.41) | KMT2AMAPTMEN1PKMSLC6A3 | |
| Phenylalanine SCHEMBL3431329 | 0.82 | DPP4 (0.41) | KMT2AMAPTMEN1PKMSLC6A3 | |
| SCHEMBL27748739 | 0.78 | CES1 (0.47) | ALDH1A1KMT2ASLC6A3TDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116656655-A | Aminopeptidase and coding gene thereof | 江苏御娘食品有限公司 | 2023-08-29 | — | — | CN | claimed |
| CN-113109333-A | Proline aminopeptidase rapid detection test paper and preparation method thereof | 桂林优利特医疗电子有限公司 | 2021-07-13 | — | — | CN | claimed |
| CN-106442989-B | A kind of Prolyl iminopeptidase detection reagent, reacting pad, preparation method and kit | 广州鸿琪光学仪器科技有限公司 | 2018-06-08 | — | — | CN | claimed |
| US-20050095660-A1 | Enzyme activities and pH tests for the determination of the risk of obstetric and gynecologic complications in samples of body fluids of women | UNIBIO, S.R.I. (IT) | 2005-05-05 | — | — | US | claimed |
| EP-1528396-A1 | Enzyme activities and pH tests for the determination of the risk of obstetric and gynecologic complications in samples of body fluids of women | UNIBIO S.R.L. (IT) | 2005-05-04 | — | — | EP | claimed |
| US-20040219617-A1 | Enzymatic test for the determination of the risk of pathologies related to the presence of sialidase or prolidase activity in women body fluid samples | UNIBIO S.R.L. (IT) | 2004-11-04 | — | — | US | claimed |
| EP-1360484-A1 | ENZYMATIC TEST FOR THE DETERMINATION OF THE RISK OF PATHOLOGIES RELATED TO THE PRESENCE OF SIALIDASE OR PROLIDASE ACTIVITY IN WOMEN BODY FLUID SAMPLES | UNIBIO S.R.L. (IT) | 2003-11-12 | — | — | EP | claimed |
| WO-2002065122-A1 | ENZYMATIC TEST FOR THE DETERMINATION OF THE RISK OF PATHOLOGIES RELATED TO THE PRESENCE OF SIALIDASE OR PROLIDASE ACTIVITY IN WOMEN BODY FLUID SAMPLES | UNIBIO S.R.L. (IT) | 2002-08-22 | — | — | WO | claimed |
| CN-118086434-A | Tuna hypoglycemic peptide and preparation method and application thereof | 中国科学院南海海洋研究所 | 2024-05-28 | — | — | CN | disclosed |
| CN-118085019-A | Tuna alpha-amylase and dipeptidyl peptidase-IV inhibition oligopeptide, and preparation method and application thereof | 中国科学院南海海洋研究所 | 2024-05-28 | — | — | CN | disclosed |
| CN-116656655-A | Aminopeptidase and coding gene thereof | 江苏御娘食品有限公司 | 2023-08-29 | — | — | CN | disclosed |
| CN-116656655-A | Aminopeptidase and coding gene thereof | 江苏御娘食品有限公司 | 2023-08-29 | — | — | CN | disclosed |
| CN-111733094-B | Bovine-derived bacillus cereus and application thereof | 内蒙古民族大学 | 2022-09-09 | — | — | CN | disclosed |
| CN-111826306-B | Bovine-derived bacillus amyloliquefaciens and application thereof | 内蒙古民族大学 | 2022-09-02 | — | — | CN | disclosed |
| US-20050095660-A1 | Enzyme activities and pH tests for the determination of the risk of obstetric and gynecologic complications in samples of body fluids of women | UNIBIO, S.R.I. (IT) | 2005-05-05 | — | — | US | disclosed |
| EP-1528396-A1 | Enzyme activities and pH tests for the determination of the risk of obstetric and gynecologic complications in samples of body fluids of women | UNIBIO S.R.L. (IT) | 2005-05-04 | — | — | EP | disclosed |
| US-20040219617-A1 | Enzymatic test for the determination of the risk of pathologies related to the presence of sialidase or prolidase activity in women body fluid samples | UNIBIO S.R.L. (IT) | 2004-11-04 | — | — | US | disclosed |
| EP-1360484-A1 | ENZYMATIC TEST FOR THE DETERMINATION OF THE RISK OF PATHOLOGIES RELATED TO THE PRESENCE OF SIALIDASE OR PROLIDASE ACTIVITY IN WOMEN BODY FLUID SAMPLES | UNIBIO S.R.L. (IT) | 2003-11-12 | — | — | EP | disclosed |
| WO-2002065122-A1 | ENZYMATIC TEST FOR THE DETERMINATION OF THE RISK OF PATHOLOGIES RELATED TO THE PRESENCE OF SIALIDASE OR PROLIDASE ACTIVITY IN WOMEN BODY FLUID SAMPLES | UNIBIO S.R.L. (IT) | 2002-08-22 | — | — | WO | disclosed |
| CN-1083112-A | A kind of method for determining bacteria and equipment | HE LIN (CN) | 1994-03-02 | — | — | CN | disclosed |