Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | HTR1F | P30939 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.37 |
| ▸ | CCR5 | P51681 | 5/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | SCD | O00767 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4081920 | 0.87 | SCD (0.40) | TACR1HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL5871706 | 0.85 | TACR1 (0.41) | TACR1HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL5871737 | 0.84 | SCD (0.45) | HTR1AHTR1DHTR1BHTR1FDRD2 | |
| SCHEMBL4076932 | 0.83 | HTR1A (0.39) | HTR1AHTR1DHTR1BHTR1FDRD2 | |
| SCHEMBL5871281 | 0.83 | TACR1 (0.41) | TACR1HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL5871341 | 0.82 | DRD2 (0.39) | HTR1AHTR1DHTR1BHTR1FDRD2 | |
| SCHEMBL5871549 | 0.81 | HTT (0.39) | TACR1HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL5871563 | 0.80 | HTT (0.39) | TACR1HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL5871626 | 0.80 | HTT (0.39) | TACR1HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL6619909 | 0.80 | HTR1A (0.46) | HTR1AHTR1DHTR1BHTR1FDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1179532-B1 | PROCESS FOR THE PRODUCTION OF INDOLE DERIVATIVES AND INTERMEDIATES THEREFOR | EISAI R&D MAN CO LTD (JP) | 2007-06-13 | — | — | EP | disclosed |
| US-6573384-B1 | 1,4-substituted cyclic amine compound which is useful as a pharmaceutical, and an intermediate for the process | EISAI CO., LTD. (JP) | 2003-06-03 | — | — | US | disclosed |
| EP-1179532-A1 | PROCESS FOR THE PRODUCTION OF INDOLE DERIVATIVES AND INTERMEDIATES THEREFOR | Eisai Co., Ltd. (JP) | 2002-02-13 | — | — | EP | disclosed |