Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 18/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 4/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202052 | 0.84 | HTR6 (0.53) | HTR6HTR2C | |
| SCHEMBL5201769 | 0.79 | HTR6 (0.58) | HTR6HTR2AHTR2BDRD3HTR2C | |
| SCHEMBL16135208 | 0.72 | HTR1F (0.59) | HTR6HTR2AHTR2BDRD3 | |
| SCHEMBL5242372 | 0.70 | CA12 (0.44) | HTR6 | |
| SCHEMBL5202025 | 0.70 | HTR6 (0.67) | HTR6HTR2ADRD3 | |
| SCHEMBL5201804 | 0.69 | HTR6 (0.56) | HTR6HTR2AHTR2BDRD3HRH3 | |
| SCHEMBL5201506 | 0.68 | HTR6 (0.47) | HTR6HTR2ADRD3HTR2C | |
| SCHEMBL4629453 | 0.67 | JAK1 (0.41) | HTR6HTR2AHRH3 | |
| SCHEMBL7256238 | 0.66 | DRD2 (0.69) | HTR6HTR2AHTR2BHRH3HTR2C | |
| SCHEMBL5205456 | 0.65 | HTR6 (0.62) | HTR6HTR2AHTR2CKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1587788-B9 | 2,7-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | HOFFMANN LA ROCHE (CH) | 2007-10-24 | — | — | EP | claimed |
| EP-1587788-B1 | 2,7-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | HOFFMANN LA ROCHE (CH) | 2007-05-16 | — | — | EP | claimed |
| CN-1314669-C | 2,7-substituted indoles and their use as 5-HT6 modulators | HOFFMANN LA ROCHE (CH) | 2007-05-09 | — | — | CN | claimed |
| EP-1587788-A1 | 2,7-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-10-26 | — | — | EP | claimed |
| CN-1681782-A | 2, 7-substituted indoles and their use as 5-HT 6 modulators | HOFFMANN LA ROCHE (CH) | 2005-10-12 | — | — | CN | claimed |
| WO-2004026830-A1 | 2,7-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-04-01 | — | — | WO | claimed |
| EP-1587788-B9 | 2,7-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | HOFFMANN LA ROCHE (CH) | 2007-10-24 | — | — | EP | disclosed |
| EP-1587788-B9 | 2,7-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | HOFFMANN LA ROCHE (CH) | 2007-10-24 | — | — | EP | disclosed |
| US-7247651-B2 | 2,7-substituted indoles | ROCHE PALO ALTO LLC (US) | 2007-07-24 | — | — | US | disclosed |
| US-7247651-B2 | 2,7-substituted indoles | ROCHE PALO ALTO LLC (US) | 2007-07-24 | — | — | US | disclosed |
| US-7247651-B2 | 2,7-substituted indoles | ROCHE PALO ALTO LLC (US) | 2007-07-24 | — | — | US | disclosed |
| EP-1587788-B1 | 2,7-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | HOFFMANN LA ROCHE (CH) | 2007-05-16 | — | — | EP | disclosed |
| EP-1587788-B1 | 2,7-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | HOFFMANN LA ROCHE (CH) | 2007-05-16 | — | — | EP | disclosed |
| CN-1314669-C | 2,7-substituted indoles and their use as 5-HT6 modulators | HOFFMANN LA ROCHE (CH) | 2007-05-09 | — | — | CN | disclosed |
| EP-1587788-A1 | 2,7-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-10-26 | — | — | EP | disclosed |
| CN-1681782-A | 2, 7-substituted indoles and their use as 5-HT 6 modulators | HOFFMANN LA ROCHE (CH) | 2005-10-12 | — | — | CN | disclosed |
| WO-2004026830-A1 | 2,7-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-04-01 | — | — | WO | disclosed |