Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 3/20 | 0.62 |
| ▸ | PLK1 | P53350 | 3/20 | 0.62 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.55 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 4/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.51 |
| ▸ | RET | P07949 | 3/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | LTK | P29376 | 1/20 | 0.51 |
| ▸ | GRK5 | P34947 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7872417 | 0.91 | MAP3K7 (0.62) | PLK4PLK1MAP3K7TAB1CHEK1 | |
| SCHEMBL8300100 | 0.91 | MAP3K7 (0.62) | PLK4PLK1MAP3K7TAB1CHEK1 | |
| SCHEMBL1389087 | 0.87 | PDPK1 (0.50) | PLK4PLK1MAP3K7TAB1CHEK1 | |
| SCHEMBL1389131 | 0.85 | DHFR (0.52) | PLK4PLK1MAP3K7TAB1CHEK1 | |
| SCHEMBL1389040 | 0.84 | TLK2 (0.55) | PLK4PLK1PDGFRBGSK3BKDR | |
| SCHEMBL15503691 | 0.81 | CHEK1 (0.60) | PLK4PLK1MAP3K7TAB1CHEK1 | |
| SCHEMBL5728227 | 0.81 | CHEK1 (0.60) | PLK4PLK1MAP3K7TAB1CHEK1 | |
| SCHEMBL5728224 | 0.81 | CHEK1 (0.60) | PLK4PLK1MAP3K7TAB1CHEK1 | |
| SCHEMBL5204214 | 0.81 | PLK4 (0.62) | PLK4PLK1MAP3K7TAB1CHEK1 | |
| SCHEMBL8300232 | 0.78 | MAP3K7 (0.72) | PLK4PLK1MAP3K7TAB1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0987263-B1 | Arylidene and heteroarylidene oxindole derivatives as tyrosine kinase inhibitors | PFIZER ITALIA SRL (IT) | 2007-04-18 | — | — | EP | claimed |