Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.39 |
| ▸ | MPL | P40238 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.38 |
| ▸ | FEN1 | P39748 | 2/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.36 |
| ▸ | CSF1R | P07333 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | FLT1 | P17948 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203520 | 0.81 | KIF11 (0.50) | KDR | |
| SCHEMBL5448863 | 0.81 | TMPRSS4 (0.44) | KDRSCN9ACYP2C9ALDH1A1LMNA | |
| SCHEMBL5442935 | 0.80 | RET (0.49) | KDRSCN9ALMNAKITPDGFRB | |
| SCHEMBL5444130 | 0.79 | KDR (0.57) | KDRRIPK1MAP4K4KITFLT3 | |
| SCHEMBL5449198 | 0.74 | CDK8 (0.53) | KDRRIPK1KITFLT3CSF1R | |
| SCHEMBL5448871 | 0.73 | TLR7 (0.38) | KDRSCN9AALDH1A1LMNA | |
| SCHEMBL5436578 | 0.73 | KDR (0.64) | KDRRIPK1ALDH1A1KITFLT3 | |
| SCHEMBL14410668 | 0.72 | TMPRSS4 (0.43) | KDRSCN9ACYP2C9ALDH1A1LMNA | |
| SCHEMBL12391453 | 0.70 | ALDH1A1 (0.49) | IKBKBALDH1A1LMNA | |
| SCHEMBL5445047 | 0.70 | RAF1 (0.51) | KDRPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761503-A2 | IMIDAZOL DERIVATIVES AS TYROSINE KINASE INHIBITORS | MERCK PATENT GmbH (DE) | 2007-03-14 | — | — | EP | disclosed |
| WO-2005097755-A2 | IMIDAZOL DERIVATIVES AS TYROSINE KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2005-10-20 | — | — | WO | disclosed |