Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | PLAT | P00750 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202219 | 0.83 | RIPK2 (0.44) | PARP1DHODHXDHBACE1NPC1 | |
| SCHEMBL5201463 | 0.81 | KDR (0.41) | KDR | |
| SCHEMBL5436578 | 0.81 | KDR (0.64) | AURKAKDRAURKBMEN1RAB9A | |
| SCHEMBL5448871 | 0.79 | TLR7 (0.38) | KDM4EXDHMAOBAURKAKDR | |
| SCHEMBL5448863 | 0.73 | TMPRSS4 (0.44) | KDM4EKDRMEN1KMT2A | |
| SCHEMBL5442935 | 0.73 | RET (0.49) | KDM4EAURKAKDRAURKB | |
| SCHEMBL12391453 | 0.72 | ALDH1A1 (0.49) | XDHMEN1NPC1RAB9AKMT2A | |
| SCHEMBL10473447 | 0.72 | KDM4E (0.42) | KIF11PARP1KDM4ESLC6A7GRIN1 | |
| SCHEMBL6509074 | 0.72 | KIF11 (0.57) | KIF11PARP1PLGPLAUPLAT | |
| SCHEMBL5444130 | 0.72 | KDR (0.57) | AURKAKDRAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761503-A2 | IMIDAZOL DERIVATIVES AS TYROSINE KINASE INHIBITORS | MERCK PATENT GmbH (DE) | 2007-03-14 | — | — | EP | disclosed |
| WO-2005097755-A2 | IMIDAZOL DERIVATIVES AS TYROSINE KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2005-10-20 | — | — | WO | disclosed |