Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 6/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | COMT | P21964 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16212535 | 0.71 | GABRG2 (0.35) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL5201498 | 0.70 | NPC1 (0.41) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL14007395 | 0.70 | COMT (0.48) | HPGDCOMTCYP3A4GRM5DRD4 | |
| SCHEMBL17267004 | 0.70 | COMT (0.48) | HPGDCOMTCYP3A4GRM5DRD4 | |
| SCHEMBL3227703 | 0.69 | GABRG2 (0.64) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL5785754 | 0.68 | NPC1 (0.50) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL790464 | 0.67 | SCN4A (0.31) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL6110315 | 0.64 | GABRG2 (0.38) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL9466146 | 0.63 | HPGD (0.40) | HPGDCOMTCYP3A4GRM5DRD4 | |
| SCHEMBL28092437 | 0.63 | CYP1A2 (0.52) | HPGDCOMTCYP3A4DRD4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1744735-A2 | METHOD OF TREATMENT OF MYOCARDIAL INFARCTION | The Scripps Research Institute (US) | 2007-01-24 | — | — | EP | disclosed |
| WO-2005089366-A2 | METHOD OF TREATMENT OF MYOCARDIAL INFARCTION | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-09-29 | — | — | WO | disclosed |