Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | USP7 | Q93009 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CPB1 | P15086 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5785754 | 0.74 | NPC1 (0.50) | NPC1RAB9ANLRP3GABRG2GABRB3 | |
| SCHEMBL3262201 | 0.70 | NPC1 (0.46) | NPC1RAB9ANLRP3MAOAMAOB | |
| SCHEMBL5201503 | 0.70 | GABRG2 (0.45) | NPC1RAB9ANLRP3GABRG2GABRB3 | |
| SCHEMBL10775340 | 0.68 | NPC1 (0.77) | NPC1RAB9ANLRP3GABRG2GABRB3 | |
| SCHEMBL3504674 | 0.68 | NPC1 (0.47) | NPC1RAB9ANLRP3MAOAMAOB | |
| SCHEMBL27354781 | 0.66 | NPC1 (0.44) | NPC1RAB9ANLRP3CYP2E1CYP2A6 | |
| SCHEMBL14481632 | 0.66 | NPC1 (0.44) | NPC1RAB9ANLRP3CYP2E1CYP2A6 | |
| SCHEMBL27798756 | 0.66 | NPC1 (0.44) | NPC1RAB9ANLRP3CYP2E1CYP2A6 | |
| SCHEMBL5366202 | 0.66 | NPC1 (0.44) | NPC1RAB9ANLRP3CYP2E1CYP2A6 | |
| SCHEMBL16038927 | 0.66 | NPC1 (0.53) | NPC1RAB9ANLRP3CYP2E1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1744735-A2 | METHOD OF TREATMENT OF MYOCARDIAL INFARCTION | The Scripps Research Institute (US) | 2007-01-24 | — | — | EP | disclosed |
| WO-2005089366-A2 | METHOD OF TREATMENT OF MYOCARDIAL INFARCTION | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-09-29 | — | — | WO | disclosed |
| US-20040214836-A1 | Method of treatment of myocardial infarction | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040214836-A1 | Method of treatment of myocardial infarction | SRC, LCK, DSTYK | NPC1 4794/4885RAB9A 4328/4885NLRP3 1499/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.