Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 14/20 | 0.76 |
| ▸ | PDE4B | Q07343 | 14/20 | 0.76 |
| ▸ | PDE4C | Q08493 | 14/20 | 0.76 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.76 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.39 |
| ▸ | TCF7L2 | Q9NQB0 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202079 | 0.89 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL5201775 | 0.88 | PDE4A (0.86) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL3534915 | 0.84 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DNPSR1 | |
| SCHEMBL292710 | 0.83 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL29824397 | 0.83 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL3533473 | 0.82 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL291798 | 0.81 | PDE4A (0.96) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL291770 | 0.77 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4DHRH4 | |
| SCHEMBL5203379 | 0.77 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL10705672 | 0.75 | PDE4A (0.84) | PDE4APDE4BPDE4CPDE4DHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819707-A2 | SUBSTITUTED PTERIDINES FOR THE TREATMENT OF INFLAMMATORY DISEASES | Boehringer Ingelheim International GmbH (DE) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006058867-A2 | SUBSTITUTED PTERIDINES FOR THE TREATMENT OF INFLAMMATORY DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-06-08 | — | — | WO | disclosed |