Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 13/20 | 0.75 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.75 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.75 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.75 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3534915 | 0.86 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL5201775 | 0.86 | PDE4A (0.86) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL5201778 | 0.82 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DCTNNB1 | |
| SCHEMBL5202079 | 0.79 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL292710 | 0.78 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL29824397 | 0.78 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL291798 | 0.76 | PDE4A (0.96) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL3537659 | 0.74 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL291770 | 0.72 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10705672 | 0.70 | PDE4A (0.84) | PDE4APDE4BPDE4CPDE4DACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7718654-B2 | Substituted pteridines for the treatment of inflammatory diseases | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-05-18 | — | — | US | disclosed |
| US-20060116371-A1 | Substituted pteridines for the treatment of inflammatory diseases | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060116371-A1 | Substituted pteridines for the treatment of inflammatory diseases | LTC4S, TLR5, LTB4R2 | PDE4A 1428/4885PDE4B 1709/4885PDE4C 1814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.