Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 14/20 | 0.50 |
| ▸ | CA12 | O43570 | 12/20 | 0.50 |
| ▸ | CA7 | P43166 | 6/20 | 0.50 |
| ▸ | CA4 | P22748 | 4/20 | 0.50 |
| ▸ | CA5A | P35218 | 4/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.50 |
| ▸ | CA3 | P07451 | 3/20 | 0.50 |
| ▸ | CA6 | P23280 | 3/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | CA1 | P00915 | 7/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.47 |
| ▸ | GLA | P06280 | 6/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | CASP1 | P29466 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1490920 | 0.77 | CA9 (0.56) | CA9CA12CA7CA4CA5A | |
| SCHEMBL5204008 | 0.74 | ALDH1A1 (0.50) | CA9CA12CA7CA4CA5A | |
| SCHEMBL5200967 | 0.74 | CA12 (0.47) | CA9CA12CA7CA4CA5A | |
| SCHEMBL5203277 | 0.74 | CA9 (0.47) | CA9CA12CA7CA4CA5A | |
| SCHEMBL15267536 | 0.73 | CA9 (0.62) | CA9CA12CA7CA4CA5A | |
| SCHEMBL29603488 | 0.72 | CA12 (0.77) | CA9CA12CA7CA4CA5A | |
| SCHEMBL3326190 | 0.72 | CA12 (0.77) | CA9CA12CA7CA4CA5A | |
| SCHEMBL5202137 | 0.70 | PGR (0.47) | CA9CA12CA7CA4CA5A | |
| SCHEMBL15171953 | 0.68 | CA9 (0.68) | CA9CA12CA7CA4CA5A | |
| SCHEMBL10350668 | 0.67 | CA12 (1.00) | CA9CA12CA7CA4CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998474-B1 | PIPERAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-02-07 | — | — | EP | disclosed |
| EP-0998474-A1 | PIPERAZINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2000-05-10 | — | — | EP | disclosed |
| WO-1999003855-A1 | PIPERAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 1999-01-28 | — | — | WO | disclosed |