Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL5201994

NCc1cccc(Oc2ccccc2N(Cc2ccccc2)C(=O)CCC(=O)NCc2cccnc2)c1.O=C(O)C(F)(F)F

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
MAPT P10636 2/20 0.41
KDM4E B2RXH2 1/20 0.41
LMNA P02545 1/20 0.41
ALDH1A1 P00352 1/20 0.40
MAPK1 P28482 2/20 0.40
TSPO P30536 1/20 0.40
EPHX1 P07099 1/20 0.40
KMT2A Q03164 3/20 0.39
HTT P42858 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
LOX P28300 1/20 0.39
LOXL2 Q9Y4K0 1/20 0.39
MEN1 O00255 1/20 0.39
SUCNR1 Q9BXA5 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL5201547 0.94 ALDH1A1 (0.40) CYP3A4CYP1A2CYP2C9CYP2C19MAPT
Trifluoroacetic Acid SCHEMBL5203223 0.93 NAMPT (0.40) CYP3A4CYP1A2CYP2C9CYP2C19MAPT
Trifluoroacetic Acid SCHEMBL5204088 0.93 MAPK1 (0.44) CYP3A4CYP1A2CYP2C9CYP2C19MAPT
Trifluoroacetic Acid SCHEMBL5207332 0.92 TPSAB1 (0.44) ALDH1A1MAPK1TSPOKMT2ALOX
Trifluoroacetic Acid SCHEMBL5202498 0.87 EPHX2 (0.38) KDM4EALDH1A1TSPOHTTSUCNR1
Trifluoroacetic Acid SCHEMBL5205473 0.87 TPSAB1 (0.39) KDM4ELMNAALDH1A1MAPK1KMT2A
Trifluoroacetic Acid SCHEMBL5205999 0.87 ALDH1A1 (0.46) ALDH1A1TSPOKMT2AMEN1
Trifluoroacetic Acid SCHEMBL5205308 0.87 TPSAB1 (0.38) MAPK1TSPOKMT2ALOXLOXL2
Trifluoroacetic Acid SCHEMBL5204427 0.87 ALDH1A1 (0.41) KDM4ELMNAALDH1A1MAPK1TSPO
Trifluoroacetic Acid SCHEMBL5205888 0.87 ALDH1A1 (0.37) KDM4ELMNAALDH1A1MAPK1TSPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7160887-B1 Aromatic amine derivatives, their production and use TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-01-09 US disclosed
EP-1123918-B1 AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME TAKEDA PHARMACEUTICAL (JP) 2005-03-09 EP disclosed
EP-1123918-A1 AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME Takeda Chemical Industries, Ltd. (JP) 2001-08-16 EP disclosed