Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.30 |
| ▸ | RAB9A | P51151 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13559609 | 0.81 | ENPP2 (0.40) | MAPTTSHRMAPK1SMN1; SMN2 | |
| SCHEMBL513729 | 0.73 | TRPV1 (0.37) | MAPTLMNATSHRMAPK1SMN1; SMN2 | |
| SCHEMBL11532078 | 0.73 | MAPK1 (0.38) | KMT2APKMMAPTLMNATSHR | |
| SCHEMBL28886 | 0.71 | APP (0.35) | KMT2AMAPTMEN1TSHR | |
| SCHEMBL17103273 | 0.69 | NOTUM (0.37) | KMT2AMAPTMEN1SMN1; SMN2 | |
| SCHEMBL16057403 | 0.69 | MAOA (0.46) | KMT2APKMMAPTLMNAMAPK1 | |
| SCHEMBL12778511 | 0.69 | ACHE (0.46) | KMT2APKMMAPTLMNAMAPK1 | |
| SCHEMBL5202160 | 0.69 | DRD1 (0.45) | KMT2APKMMAPTLMNARAB9A | |
| Hydrochloric Acid SCHEMBL9124177 | 0.69 | CYP3A4 (0.33) | KMT2AMAPTMEN1TSHR | |
| SCHEMBL3934082 | 0.68 | CYP1A2 (0.63) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |