Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 7/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 7/20 | 0.48 |
| ▸ | HTR2C | P28335 | 7/20 | 0.48 |
| ▸ | HTR2B | P41595 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202293 | 0.84 | THRB (0.49) | HRH2HTR2AHTR2CHTR2BMAPT | |
| SCHEMBL4852934 | 0.82 | HRH2 (0.50) | HRH2HTR2AHTR2CHTR2BMAPT | |
| SCHEMBL5205779 | 0.81 | HRH2 (0.49) | HRH2HTR2AHTR2CHTR2BMAPT | |
| SCHEMBL5203370 | 0.81 | HRH2 (0.47) | HRH2HTR2AHTR2CHTR2BMAPT | |
| SCHEMBL4858756 | 0.80 | SLC2A1 (0.49) | HRH2HTR2AHTR2CHTR2BMAPT | |
| SCHEMBL5204484 | 0.80 | SLC2A1 (0.47) | HRH2HTR2AHTR2CHTR2BMAPT | |
| SCHEMBL5203382 | 0.80 | MAPT (0.46) | HRH2HTR2AHTR2CHTR2BMAPT | |
| SCHEMBL4859761 | 0.80 | HRH2 (0.48) | HRH2HTR2AHTR2CHTR2BMAPT | |
| SCHEMBL4857604 | 0.79 | MAPT (0.53) | HRH2HTR2AHTR2CHTR2BMAPT | |
| SCHEMBL5204486 | 0.79 | MAPT (0.54) | HRH2HTR2AHTR2CHTR2BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |