Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | HTR2C | P28335 | 3/20 | 0.45 |
| ▸ | HTR2B | P41595 | 3/20 | 0.45 |
| ▸ | HRH2 | P25021 | 2/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.45 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202930 | 0.87 | SLC2A1 (0.59) | MAPTLMNAALDH1A1NPSR1HTT | |
| SCHEMBL4852934 | 0.87 | HRH2 (0.50) | MAPTLMNAALDH1A1NPSR1HTT | |
| SCHEMBL5205779 | 0.86 | HRH2 (0.49) | MAPTLMNAALDH1A1NPSR1HTT | |
| SCHEMBL5203370 | 0.86 | HRH2 (0.47) | MAPTLMNAALDH1A1NPSR1HTT | |
| SCHEMBL4857604 | 0.82 | MAPT (0.53) | MAPTALDH1A1RAB9ASMN1; SMN2HTR2A | |
| SCHEMBL5202293 | 0.82 | THRB (0.49) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL4859761 | 0.81 | HRH2 (0.48) | MAPTMEN1KMT2AHTR2AHTR2C | |
| SCHEMBL5483292 | 0.81 | PKM (0.39) | MAPTLMNAALDH1A1NPSR1HTT | |
| SCHEMBL5818040 | 0.81 | SLC2A1 (0.47) | MAPTLMNAALDH1A1NPSR1HTT | |
| SCHEMBL4859500 | 0.80 | KMT2A (0.52) | MAPTLMNAALDH1A1NPSR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |