Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 2/20 | 0.44 |
| ▸ | DHODH | Q02127 | 3/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12391453 | 0.82 | ALDH1A1 (0.49) | ALDH1A1LMNAXDHGRM1NPC1 | |
| SCHEMBL5447368 | 0.80 | KDR (0.52) | CSF1RFLT1FLT3MAP4K4LIMK1 | |
| SCHEMBL4877916 | 0.72 | ALDH1A1 (0.41) | ALDH1A1LMNANPC1RAB9AKMT2A | |
| SCHEMBL5447338 | 0.70 | KDR (0.55) | CSF1RFLT1FLT3MAP4K4NPC1 | |
| SCHEMBL12394209 | 0.70 | DHODH (0.64) | DHODHCSF1RFLT1FLT3PARP1 | |
| SCHEMBL6508388 | 0.69 | ITK (0.47) | ALDH1A1LMNACSF1RFLT1FLT3 | |
| SCHEMBL5201463 | 0.69 | KDR (0.41) | ALDH1A1LMNACSF1RFLT1FLT3 | |
| SCHEMBL19878461 | 0.69 | MKNK1 (0.47) | RIPK2DHODHTLR8CSF1RFLT3 | |
| SCHEMBL5440835 | 0.69 | KDR (0.53) | LMNACSF1RFLT1FLT3NPC1 | |
| SCHEMBL3534998 | 0.68 | ALDH1A1 (0.46) | ALDH1A1LMNAKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761503-A2 | IMIDAZOL DERIVATIVES AS TYROSINE KINASE INHIBITORS | MERCK PATENT GmbH (DE) | 2007-03-14 | — | — | EP | disclosed |
| WO-2005097755-A2 | IMIDAZOL DERIVATIVES AS TYROSINE KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2005-10-20 | — | — | WO | disclosed |