Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | IGF2BP1 | Q9NZI8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | SMO | Q99835 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13445248 | 0.81 | SMO (0.57) | SLC2A1HTR2AHTR2CHTR2BSMO | |
| SCHEMBL5201634 | 0.79 | SLC2A1 (0.47) | ALDH1A1SLC2A1LMNAHTR2AHTR2C | |
| SCHEMBL4859724 | 0.79 | SMO (0.46) | ALDH1A1SLC2A1LMNAHTR2AHTR2C | |
| SCHEMBL5202604 | 0.79 | SLC2A1 (0.46) | SLC2A1HTR2AHTR2CHTR2BSMO | |
| SCHEMBL4861849 | 0.78 | KDM1A (0.46) | ALDH1A1SLC2A1LMNAHTR2AHTR2C | |
| SCHEMBL5203146 | 0.78 | SMO (0.47) | ALDH1A1SLC2A1LMNAHTR2AHTR2C | |
| SCHEMBL5202216 | 0.77 | SMO (0.49) | ALDH1A1SLC2A1LMNAHTR2AHTR2C | |
| SCHEMBL3599338 | 0.77 | SLC2A1 (0.55) | ALDH1A1TSHRSLC2A1HTR2AHTR2C | |
| SCHEMBL4853409 | 0.75 | SLC2A1 (0.50) | ALDH1A1SLC2A1LMNAHTR2AHTR2C | |
| SCHEMBL5206911 | 0.73 | SLC2A1 (0.57) | ALDH1A1TSHRSLC2A1LMNAHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |