Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 4/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5201634 | 0.79 | SLC2A1 (0.47) | SMOHTR2AHTR2CHTR2BSLC2A1 | |
| SCHEMBL4859724 | 0.78 | SMO (0.46) | SMOHTR2AHTR2CHTR2BSLC2A1 | |
| SCHEMBL13445248 | 0.78 | SMO (0.57) | SMOHTR2AHTR2CHTR2BSLC2A1 | |
| SCHEMBL5202604 | 0.78 | SLC2A1 (0.46) | SMOHTR2AHTR2CHTR2BSLC2A1 | |
| SCHEMBL5202596 | 0.77 | ALDH1A1 (0.47) | SMOHTR2AHTR2CHTR2BSLC2A1 | |
| SCHEMBL4861849 | 0.76 | KDM1A (0.46) | SMOHTR2AHTR2CHTR2BSLC2A1 | |
| SCHEMBL5205834 | 0.72 | SMO (0.48) | SMOHTR2AHTR2CHTR2BSLC2A1 | |
| SCHEMBL3599338 | 0.72 | SLC2A1 (0.55) | SMOHTR2AHTR2CHTR2BSLC2A1 | |
| SCHEMBL5203814 | 0.71 | SMO (0.51) | SMOHTR2AHTR2CHTR2BSLC2A1 | |
| SCHEMBL5202142 | 0.71 | LMNA (0.50) | SMOSLC2A1HRH2KDM1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |