Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.46 |
| ▸ | SMO | Q99835 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | HTR2B | P41595 | 3/20 | 0.43 |
| ▸ | HRH2 | P25021 | 5/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | CFD | P00746 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202596 | 0.79 | ALDH1A1 (0.47) | SLC2A1SMOHTR2AHTR2CHTR2B | |
| SCHEMBL5201634 | 0.78 | SLC2A1 (0.47) | SLC2A1SMOHTR2AHTR2CHTR2B | |
| SCHEMBL4859724 | 0.78 | SMO (0.46) | SLC2A1SMOHTR2AHTR2CHTR2B | |
| SCHEMBL5202216 | 0.78 | SMO (0.49) | SLC2A1SMOHTR2AHTR2CHTR2B | |
| SCHEMBL4861849 | 0.77 | KDM1A (0.46) | SLC2A1SMOHTR2AHTR2CHTR2B | |
| SCHEMBL13445248 | 0.77 | SMO (0.57) | SLC2A1SMOHTR2AHTR2CHTR2B | |
| SCHEMBL3599338 | 0.71 | SLC2A1 (0.55) | SLC2A1SMOHTR2AHTR2CHTR2B | |
| SCHEMBL5203146 | 0.70 | SMO (0.47) | SLC2A1SMOHTR2AHTR2CHTR2B | |
| SCHEMBL5205834 | 0.69 | SMO (0.48) | SLC2A1SMOHTR2AHTR2CHTR2B | |
| SCHEMBL5206733 | 0.69 | SCD5 (0.47) | SLC2A1SMOHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |