Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | SMO | Q99835 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | FNTA | P49354 | 2/20 | 0.41 |
| ▸ | FNTB | P49356 | 2/20 | 0.41 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4859724 | 0.84 | SMO (0.46) | SLC2A1SMOKDM1AHRH2MEN1 | |
| SCHEMBL4861849 | 0.80 | KDM1A (0.46) | SLC2A1SMOKDM1AHRH2MEN1 | |
| SCHEMBL5202216 | 0.79 | SMO (0.49) | SLC2A1SMOKDM1AHRH2HTR2A | |
| SCHEMBL5202596 | 0.79 | ALDH1A1 (0.47) | SLC2A1SMOKDM1AHRH2HTR2A | |
| SCHEMBL13445248 | 0.78 | SMO (0.57) | SLC2A1SMOKDM1AHRH2MEN1 | |
| SCHEMBL5202604 | 0.78 | SLC2A1 (0.46) | SLC2A1SMOKDM1AHRH2MEN1 | |
| SCHEMBL3599338 | 0.77 | SLC2A1 (0.55) | SLC2A1SMOHRH2HTR2AHTR2C | |
| SCHEMBL5201977 | 0.77 | SLC2A1 (0.46) | SLC2A1HRH2MEN1KMT2ADRD2 | |
| SCHEMBL4859525 | 0.75 | SLC2A1 (0.63) | SLC2A1HRH2MEN1KMT2AHTR2A | |
| SCHEMBL5206978 | 0.75 | SLC5A1 (0.49) | SLC2A1HRH2HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |