Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3468860 | 0.79 | ESR1 (0.56) | SLC6A2SLC6A3ESR1ESR2APP | |
| SCHEMBL6574222 | 0.79 | MAOB (0.53) | CA12CA2CA3CA6CA9 | |
| SCHEMBL634910 | 0.78 | LTA4H (0.45) | LTA4HMEN1KMT2ASYK | |
| SCHEMBL10610940 | 0.78 | GAA (0.58) | LTA4HLMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL27895120 | 0.78 | LMNA (0.41) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL27925496 | 0.77 | EGFR (0.39) | SYK | |
| SCHEMBL4652388 | 0.77 | APP (0.50) | APPSYK | |
| SCHEMBL3472112 | 0.77 | SYK (0.43) | CA12CA2CA9SYK | |
| SCHEMBL975819 | 0.77 | CA12 (0.53) | LTA4HLMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL2641227 | 0.77 | LTA4H (0.47) | LTA4HLMNACYP1A2PTGS1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0887346-B1 | N-Phenyl-alkylsulfonamide derivatives, their preparation and their use as alpha1A/1L adrenoceptor agonists | HOFFMANN LA ROCHE (CH) | 2007-12-12 | — | — | EP | disclosed |
| US-6057349-A | ALPHA.SUB.1A/1L AGONISTS USED IN THE TREATMENT OF VARIOUS DISEASE STATES SUCH AS URINARY INCONTINENCE, NASAL CONGESTION, PRIAPISM, DEPRESSION, ANXIETY, DEMENTIA, SENILITY, ALZHEIMER'S, DEFICIENCIES IN ATTENTIVENESS AND COGNITION, AND | F. HOFFMAN LA ROCHE AG (CH) | 2000-05-02 | — | — | US | disclosed |
| US-5952362-A | INHIBITOR OF GLYCOGEN PHOSPHORYLASE ENZYMETIC ACTIVITY AND GLUCOSE ACITIVITY | SYNTEX (U.S.A) INC. (US) | 1999-09-14 | — | — | US | disclosed |
| EP-0887346-A2 | Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives, their preparation and their use as alpha1A/1L adrenoceptor agonists | F. HOFFMANN-LA ROCHE AG (CH) | 1998-12-30 | — | — | EP | disclosed |
| EP-0129851-B1 | PREPARATION OF MONOALKYLATED DIHYDROXYBENZENES AND NOVEL COMPOUNDS PREPARED THEREBY | THE DOW CHEMICAL COMPANY (US) | 1988-07-13 | — | — | EP | disclosed |
| US-4691042-A | Preparation of monaoalkylated dihydroxybenzenes and novel compounds prepared thereby | THE DOW CHEMICAL COMPANY (US) | 1987-09-01 | — | — | US | disclosed |
| US-4568497-A | Preparation of monoalkylated dihydroxybenzenes | THE DOW CHEMICAL COMPANY (US) | 1986-02-04 | — | — | US | disclosed |
| US-4511731-A | 2-Ethoxyethyl 2-(4-hydroxyphenoxy)-propanoate | THE DOW CHEMICAL COMPANY (US) | 1985-04-16 | — | — | US | disclosed |
| EP-0129851-A2 | Preparation of monoalkylated dihydroxybenzenes and novel compounds prepared thereby | THE DOW CHEMICAL COMPANY (US) | 1985-01-02 | — | — | EP | disclosed |