Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | LMNA | P02545 | 7/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HRH2 | P25021 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.44 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5204486 | 0.87 | MAPT (0.54) | SLC2A1ALDH1A1LMNANPSR1HTT | |
| SCHEMBL5818040 | 0.87 | SLC2A1 (0.47) | SLC2A1ALDH1A1LMNANPSR1HTT | |
| SCHEMBL4859827 | 0.85 | SLC2A1 (0.61) | SLC2A1ALDH1A1LMNANPSR1HTT | |
| SCHEMBL14181452 | 0.80 | SLC2A1 (0.57) | SLC2A1ALDH1A1LMNANPSR1HTT | |
| SCHEMBL5203232 | 0.80 | LMNA (0.51) | ALDH1A1LMNANPSR1HTTPOLB | |
| SCHEMBL5206324 | 0.80 | SLC2A1 (0.50) | SLC2A1ALDH1A1LMNANPSR1HTT | |
| SCHEMBL5201638 | 0.79 | SLC2A1 (0.49) | SLC2A1ALDH1A1LMNANPSR1HTT | |
| SCHEMBL4859500 | 0.79 | KMT2A (0.52) | ALDH1A1LMNANPSR1HTTSMN1; SMN2 | |
| SCHEMBL4859525 | 0.78 | SLC2A1 (0.63) | SLC2A1ALDH1A1LMNANPSR1HTT | |
| SCHEMBL3615414 | 0.77 | SLC2A1 (0.64) | SLC2A1ALDH1A1LMNANPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |